2016: The Year Of My Great Depression


the worst year ever.

2016 wasn’t only just the worst year ever, it was also the year I turned 30, founded my own feminine wellness company, and brought an amazing puppy home. So not all bad. Light does find a way of shining through the darkness. And what is the darkness I’m referring to? Crippling anxiety and depression at the hands of a severe vitamin deficiency that went undiscovered for 16 months.

I started feeling very off in the fall of ’15. Racing mind, impulsive behavior, insomnia. That all developed into a feeling of anxiety that lasted for almost 2 months without any relief. I mean, can you imagine having a 60 day long panic attack? I can now – I lived it. On top of all of this, imagine that you have no idea why your body is turning itself inside out, your brain feels like it’s on Pluto, and your sweet boyfriend is wondering what the fuck is going on. The unknown is certainly a terrifying place.

2016 arrives, and so does the therapy and the medication. I feel okay for moments of time, and then plunge back into the darkness again and again. The anti-depressant cycle is a vicious one – especially if you don’t actually require one, but that moment of enlightenment won’t arrive for another 9 months. Up and down, up and down. Tears, moments of extreme highs, confusion about why you don’t feel completely back on your feet after the standard 4-6 weeks of allowing the meds to “kick in”. Making changes and adjustments to medications more than 4 times. Exercise helps, my relationship helps, my family helps. But, the underlying, creeping feeling that there may not be a silver bullet to my problems, and that this state of disarray may be the new “me” keeps me feeling stagnant. I wouldn’t wish my 2016 on my worst enemy.

September arrives. My doctors are confused by my lack of progress. Finally, a complex blood test to look at my vitamin levels is ordered. A week later, a transformative call lights up my phone and ultimately, my life. I’m told I have severe deficiencies of Vitamins B12 and Vitamin D. Want to know what happens if you’re deficient? You can develop, amongst other things, depression, anxiety, fatigue, headaches, dizziness, and a lot of other vague and uncomfortable symptoms. Want to know what happens if you never address your deficiencies? The symptoms can become permanent – yes, like permanent brain damage.

So how can a seemingly healthy 30 year old woman, who is a professional chef and makes quite a point to responsibly source food and eat healthy have vitamin deficiencies? The story gets more complex. I was so shocked by my results I absolutely had to know more, and I absolutely felt hopeful for the first time in over a year. I went into health-discovery overdrive. I saw eastern medicine doctors, holistic practitioners, acupuncturists, chiropractors, and got genetic testing done (quite easily too, through 23andme). My raw genetic details would reveal that I have mutations in the MTHFR and MAOA genes, indicating why a woman who does everything right on the outside may not feel so great on the inside. The field of genetics is a brilliant, developing one. I truly believe that how we perceive personal healthcare will completely change over the next 10 to 20 years as this area grows and more people are clued in to just how personal you can get with your health.

What I know now is why my body doesn’t process B12 and D in the way that other people can. I also know how to handle this problem – which is by taking the highest quality, most bio-available methylated form of both every single day for the rest of my life. For the few first weeks, I routinely stabbed myself in the stomach with needles full of prescription liquid B12.  A kick-ass probiotic helps too. I always kind of scoffed at people who gulped down 30 vitamins a day, thinking of them as snake oil pills, and fools for being suckered by the vitamin industry, but fuck man, this shit works. 6 months later, after following a strict regime everyday I literally feel 100% back to normal. Better even than I did in 2014 and most of 2015 leading up to The Great Depression. I’m confident that my deficiencies had been brewing for much longer than just a few months.

During my struggle I could barely process my emotions, let alone work a full 9-5 on YouTube videos, Love Wellness, or TheLoDown. I’ve lost so much, and gained so much on the other side too. I’ve grown as a human in ways I didn’t think possible. I dealt with all the ickiness inside of me that could at times make me behave badly, treat others poorly, and not take great emotional care of myself (therapy, man). Depression and anxiety can be both emotional and physical, and having lived through it, all I can say is that the struggle is worth it. I resent it, I hate it, it’s fucked up my world – but I also see it for what it is, and that’s quite beautiful. Life happens, and if it happens to you – how will you handle it? I’m living proof that you should fight, you should explore, you should take your health into your own hands and be your own advocate, and that you CAN come out the other side with some serious scars, but feeling like a brand new human being.

For a list of the vitamins I’m taking, see below:

  1. Blisphora (methylated Vitamin B12 with folate)
  2. Vitamin D3 with K
  3. Magnesium
  4. Circumin (Turmeric)
  5. Serenol (for symptoms of PMS) – the jury is still out on this one
  6. Good Girl Probiotics (vaginal health/wellness)
  7. Perfect Condition Vitamin (vaginal health/wellness)
  8. Omega 3s

P.S. – there are HUGE discrepancies in quality between vitamin companies so definitely do your research before hittin’ up the vitamin aisle at Duane Reade. I like to make the comparison between cheap, readily available brands and ones of greater cost to that of fast food and farm to table eating, if you catch my drift. Be Well!

  1. Thank you for posting!!! I have noticed some of the same side effects in my life and recently learned I’m extremely VD deficient. I was prescribed a high dose of VD over a 3 month period but that is almost over and I’m looking for a good daily replacement. Would you share the brands you use of the supplements you list above?

  2. Thanks for sharing. I can relate, as i realized I had severely low iron a few years ago and was relieved in a way when I found out it may have contributed to my depressive bouts. I really did not want to go on anti-depressants. My Doctor then told me going on the pill might help as my hormones might have been a factor. A few years later all that did was make me gain more weight. I am now working with a dietitian to help me heal using food, vitamins and supplements! You can read more about my food story and my “I am Balanced” project on my blog at http://www.aftertheharvest.ca/blog

      1. I also suffered from unexplained severe iron deficiency, to the point where i had to get iv’s of iron at the hospital 3 times a week. Also had low b12 (had to give myself shots) and low vitamin d. Finally after seeing a hematologist, i was diagnosed with celiac disease which was confirmed via biopsy w/gastro doc. My body was not able to absorb any nutrients. The only cure is a gluten free diet. Its worth checking out if you both have not already. Celiac has many “silent” symptoms and often gets overlooked due to it mimicing other conditions.

  3. i was having severe headaches about a year ago (constantly) and got tested only to find out a severe Vitamin D & B12 deficiency as well! i must not have done enough research to link it to how i’ve been feeling for a while now. i guess it’s hard to say “i’m depressed” but all the symptoms line up πŸ˜”

  4. This gives me hope reading this! I have been experiencing heightened anxiety for the last couple years and thought it was tied to birth control and a stressful job. But I do am low in B12 and D, but have been terrible at keeping up with taking them daily. Definitely going to work on taking it more often now!

  5. Lo, you don’t know how much I needed this! I have struggled with anxiety and depression the last three years, with ups and downs. The most recent down was last week when i was in a complete fog, on the verge of tears, and couldn’t find joy in anything. Thank god for therapy and medication. I just hope to be off medication eventually. As for vitamins, they are powerful! I was getting weekly migraines last fall so I started taking magnesium and B2 daily and my migraines are GONE! Thanks for sharing your story! xx.

  6. This describes me to a T! What tests did you get done or ask your doctor to do other than the blood test? Or was that one it?

    1. just ask for a test that checks your vitamin levels, thyroid, etc. once you get the results – make sure you do some of your own research on what your numbers mean!

  7. Hi, thank you so much for sharing your story. I also suffer from anxiety that got very bad when I was in my early 30s. I was wondering if you experienced depersonalization as part of your anxiety? I find that symptom the absolute worst. I recently began taking vitamin D and have noticed less overall anxiety.

  8. I, too, have a low B12, but not sure if it’s considered deficient. The doctors didn’t seem concerned, but I have similar symptoms that you described. If you don’t mind sharing what were your B12 levels? Mine were 360.

  9. Thank you for sharing. I have MTHFR and found out after having my stillborn son. I hope that you read these and take into consideration the importance of MTHFR and pregnancy affects. Thanks again.

  10. I commented on Youtube as well but I just want to say thank you so much for posting this information. You are truly brave and so kind to do so. Many Thanks!

  11. Hi I also have the MTHFR gene mutation and there is a lot that this can effect negatively. Not only can one not process certain vitamins but you easily build up toxins and are much more at risk for clotting issues such as heart attack, miscarriage, etc. for pregnancy you need to take baby aspirin thru week 36. Have your homocysteine levels checked annually. Read MTHFR.net and join the groups on FB that are for MTHFR and specifially which mutation you have. Do your research, the medical community still widely dismisses this as a real issue but for those of us that have this we know otherwise. Also stay away from nitris oxide at the dentist, it can be fatal for people with this mutation . There are many things that can also inhibit your b consumption further because of this mutation and not good to take such as Antacids, Tylenol, etc.

    1. This! Also wanted to add that if you have MTHFR mutations of any kind you should avoid all forms of synthetic vitamins which means anything that is “enriched” or “fortified” (bread, pasta, milk, juice, crackers, rice, etc.) has synthetic vitamins *check the label*. Folic Acid, Riboflavin, Thiamine Mononitrate, Thiamine Hydrochloride, Cyanocobalamin are all manmade and synthetic and should not be consumed if you have these mutations.

      1. Lo,My daughter is going through the same thing! Additionally, she has gained a lot of weight, is training and cannot lose a pound. She is working with a trainer who is worried about her health. She was recently tested and has virutally no Vitamin D, MTHFR, and Factor V. Doctors do not know why she has gained a lot weight, eating clean planned by the trainer, and cannot lose a single pound. Trainer thought she had thyroid problems, but her numbers were in the normal range.

        1. Jan – I have the exact same issues as your daughter (I’m 27). I gained a significant amount of weight and my Dr. thought it might be thyroid but results were fine. I had a blood test in January and found out about my Vitamin D deficiency and found out about my MTHFR last year after doing 23 and Me for fun. I’m really struggling to lose the weight too and I’m sorry I have no tips to help but it’s comforting to know there is someone else going through the same thing as me.

          1. OMG!!! She is a goreous girl and is not used to being overweight so that in itself is depressing when you eat healthy and clean, exercise, weigh your food so that you are eating the correct amount of protein etc. Her doctor says theres an underlying reason she has gained this amount of weight. She wants her to go to see an endocronologist! SO frustrating!Thanks for responding!

          2. Do you recommend the Leptin supplements too? If so, which type? Any side effects?

        2. It’s Leptin. She can easily lose if she follows a leptin reset diet. I have the MTHFR mutation, trust me, it’s leptin. Don’t let them throw this nonsense at her re thyroid, it’s leptin.

        3. DId they check her Thyroid peroxidase antibody (TPO) too? You can have the typical thyroid tests in the normal range, but many docs don’t also test for TPO which tests for autoimmune thyroid disease like Hashimotos.

  12. Thank you so much for being brave enough to share this. I am currently experiencing overwhelming anxiety that had spiraled into depression. I attribute it to an awful work situation and on-going health issues but will look into vitamins to try and help me feel a bit better. it’s so hard to go through this especially when people around you don’t understand.

  13. Wow. Thanks so much for sharing. I would have never known that a Vitamin deficiency could lead to depression. Depression/Anxiety is so far from black/white, it is always helpful to hear how other people have dealt with it.
    Brittany | thechicette.com

  14. So nice to hear you sharing this. I hope you know you have truly made a difference in my life. Sometimes you start to feel alone when having issues like these. My anxiety is out of control and seems to be taking over my life. I still try to find the positive in everything but really finding the issue would be great. Do you just recommend going to the doctor and talking these test?
    Thanks again. Xoxo.

    1. I guess I’d speak to your practitioner about your issues and ask for a full health screening, including tests that go much deeper than the most basic blood test.

  15. Hi,
    I’ve very recently started having depression and anxiety- out of no where. How much are you taking of each of these? Do you take them at certain times of the day? Thanks for sharing, sure helps to know there is a light at the end of the tunnel. xo!

  16. I, too, have a low B12, but not sure if it’s considered deficient. The doctors didn’t seem concerned, but I have similar symptoms that you described. If you don’t mind sharing what were your B12 levels? Mine were 360.

  17. Thank you for sharing, Lo! Webber Naturals + Natural Factors Group make amazing, effective vitamins. They work really well!

  18. Hi thank you for bringing MTHFR to people’s attention! It’s such an important topic and as you said is mostly dismissed by the medical community. I have the double mthfr mutation I am homozygous for mthfr c677t and found out after having several late miscarriages. I am curious to know if you are comfortable sharing which MTHFR mutation you have? Also I am having such a hard time getting on the methylated b12 and folate it makes me feel trrrible. am curious if you had a hard time with it and any tricks? I keep giving up even though I know I need it. Again thank you for bringing mthfr to the forefront!

  19. Thank you so much for this post, itw comforting to hear you had a similar experience to me, not that I would wish it on anyone. I have pernicious anaemia, iron and b12 deficiency sue to H-Phlori, a bacteria I experienced jn my gut which now means I cannot absorb b12. I get an injection every 3 months from my local doctors surgery. I had never heard of the gene mutation before, very interesting. Delighted to hear you are doing much better and tackling it head on. It’s something I am so conscious of but grateful to be able to manage it. I’ve always been a fan of yours and hope that another girl reading this blog may be helped too. Thank you

  20. So thankful you shared this! I read this and felt like I was reading about myself. I’m 25 and just learned a few weeks ago that I have a b12 deficiency. I have had a lot of anxiety and depression over the last month. Do you take an anti depressant with your vitimans? If so does it help?

  21. thank you SO MUCH for sharing this! i too have MTHFR. it was recently discovered while going through IVF. i too have struggled with anxiety and taking the methylated B vitamins and proper folate has helped. you’ll likely have to be on blood thinners while pregnant and take extra folate but it’s so great that you were your own advocate and figured this out now! thanks again for being so open and honest!

  22. Hello Lo,
    I too have terrible depression for years now. I’ve been on so much medication, therapy, diet changes, etc. It also seems to get much worse before my time of the month. Are there any cost effective alternatives to Blisphora? I am desperate to try anything, but I don’t think I can afford it every month. Thank you!

  23. This really has me thinking about whats going on with me. I developed anxiety around studying for the bar exam. I never passed but love what I do now, however, I recently have been lying awake at night with anxiety again. I think I need a physical with a vitamin test or I might just try taking these two vitamins as I currently don’t take any.Thanks for sharing!

  24. Thank you for being honest in your struggles. It’s so important for people like yourself who have a wider audience to share your story and I commend you for it. I am a 39 year old hypothyroid mama with 3 amazing boys and have developed HELLP syndrome (a more severe form of pre-eclampsia) with all of them. They are all happy and healthy 13, 10 and 4 year old cutie pies. This is another thing related to the MTHFR mutation. I also suffer from very low D, B12 and Iron. Since December I have been on a nightmare rollercoaster of anxiety and panic attacks. Thank you for posting the vitamins that are helping you and thank you again for sharing your story. It sometimes helps just to know that we are not alone! πŸ™‚

  25. My 6 year old son has a mutated (double copy) version of MTHFR. He had some developmental delays when he was younger and behavioral problems (which are much better now) and we did blood work and discovered it. B12 deficiencies are definitely part and parcel with MTHFR, but the biggest issue is your bodies ability to process folate…or lack there of. Even if you eat a lot of leafy greens or liver (which surprisingly has a ton of folate) it’s still difficult so you need to take supplements, namely methyl folate. A lot of doctors will prescribe Deplin which is basically the pharmaceutical industry’s version of methylated folate. I think it has some vitamin E in it too which helps your body absorb it better but if you don’t want to bother with prescription drugs you can always find methyl folate at a vitamin store or whole foods etc. Take some vitamin E with it too if you want. But the key thing is to avoid folic acid. A lot of people think folic acid and folate are the same but they are NOT. Folic acid is a synthetic vitamin (i.e. man made, not found in nature) that the govt started fortifying pasta and bread and cereal with back in the 70’s because it was thought be good for everyone, especially pregnant women. It is not however good for people with MTHFR because they can not process it and it leads to high levels in the body which can lead other problems. If you or your kid with MTHFR likes cereal and pasta and bread (like most of us) then just look for organic brands that do not have folic acid. WF organic pasta does not have folic acid and a lot of cereals and breads don’t either. Just look on the label. And take methylfolate pills. On the B12 front, definitely take methyl B12 (which breaks the blood brain barrier). Regular B12 (cyancobaline) is absolutely worthless as your body does not process 99% of it. That said, even though methyl B12 is in it’s active form and can break the blood brain barrier it is still mostly destroyed by your stomach when digested so shots or nasal spray is by far the most effective. While I haven’t been tested for MTHFR I am convinced I have a mutated version too as I have always suffered from anxiety and other things asserted with MTHFR. I plan to do bloodwork myself. Apologies if I am reiterating a lot of stuff that’s been covered. I didn’t go through everyones comments. I just started writing because I am fascinated by this and want t help people…because it can by alleviated through changes in diet and supplements.

  26. Lo, I had the exact same hell seemingly out of nowhere when I turned 39 a few years ago..Crazy weight swings, depression, panic attacks etc. I was low in Vitamin s D and B 12 and had the MTHFR inability to absord, etc – BUT the main thing was that my thyroid was completely out of whack..Definitely get your antibodies tested as that could be a big part of it..If your endocrine system is screwed up, it affects pretty much everything else.

  27. It looks like the “Perfect Condition Vitamin” has Folic acid in it not Folate. Or at least that what the info says on it. I would take something different than that one.

    1. YES, SHE IS HURTING HERSELF WITH FOLIC ACID. However, I believe she said folate, which is not folic acid.

      1. look at the ingredients. Folic Acid is second on the list of Perfect Condition Vitamin. Otherwise, sounds great if it didn’t have it!

  28. You might want to get B12 injections. Also, get a blood test to check for Pernicious Anemia. Make sure you have low levels of Homocysteine and Methylmalonic Acid. Also, check for Parietal Cell Antibodies and Intrinsic Factor Antibodies.

    1. Hopefully a good Dr would have done the antibodies test. Mind did after I was found to have extremely low B12.

      1. Antibodies are for microbes. The only value in that is to discover a microbe that has pushed immunity systems. For MTHFR, antibodies–themselves–mean nothing.

    2. They don’t work. The B12 needs to be taken in small doses WITH methylfolate every day. One shot of it will just build up in the system and not be processed. Small doses, every single day.

      1. You don’t know what you’re talking about. If you have Pernicious Anemia and don’t get B12 injections, you die.

  29. Hi Lo,I am so glad to see someone bringing attention to this mutation and the effects it can have. I found out that I have the C677T MTHFR mutation a couple of years ago. I have researched vitamins and supplements to help with my mutation, starting with the injections and moving on to oral vitamins. One thing I wanted to mention, after looking at your vitamin list, is that the Perfect Condition Vitamin has a pretty large dose of folic acid. Most physicans suggest that those of us who need the methylated versions of B12 and folate should steer clear of consuming folic acid, as it blocks receptors from being able to absorb the useable folate. I’m not sure if this is an issue you have, but I figured I would mention it because of the researching I have done. Folic acid is added to so many foods and supplements, it’s a task to weed them all out.
    Anyway, thank you again for highlighting this issue, so many people have no idea it exists. It’s so wonderful to see someone talking about it!

    1. I am homozygous C677T and 99% of the doctors I visited failed me. The research of Dr. Rich Van Konynenburg is the best, he was particularly good with the community. Very sadly, he passed away a few years back, but his work continues to be shared worldwide. Without his discoveries of methylation block, this community would be lagging behind in viable treatments. I have been highly successful and I never truly believed in chronic fatigue, but it hit me between the eyes after a bout with strep. Unreal. Rich VanK was the only way out after wasting time, money and valuable energy on “regular” physicians.

  30. I have autoimmune B12 deficiency- Pernicious anemia. My immune system attacks the protein that absorbs B12- so I have to do shots- you get use to them.I went to the Dr thinking my thyroid was out of whack- dry skin, hair falling out, exhaustion. He suggested the B12- my levels was under 200- terrible! I do get mild depression when my levels drop. I have known others to have slurred speach & motor issues. B12 helps your body make red blood cells- so it is crucial.
    It’s also a cheap & easy test and a relatively easy & cheap treatment. Doctors learn about early in medical school- so they often don’t think of it with young people. It’s always good to ask for it in your routine blood work- same goes for any elderly people you know. They can have poor diets & the result is B12 deficiency.

    Thanks for sharing your story & getting out the word about this subject!

  31. Hi, thank you for sharing – this is so important. I am glad you are feeling better! I also suffered from severe depression, anxiety, and fatigue for years. Antidepressants and therapy weren’t helping much – it was very serious and life-threatening. Finally, after YEARS… a routine physical with a very thorough physician. She did a comprehensive metabolic blood panel. To my complete shock, I was sent to the ER that day. I had critically low levels of potassium but I had no physical symptoms (vomiting, diarrhea, muscle spasms). I was also severely vitamin D deficient. Turns out, I have a rare potassium-wasting disorder. I can’t tell you how many doctors and hospitals missed this over the years. Being on supplements and medication for this has turned my life around. I feel great. I love life. I AM SO GLAD I DIDN’T GIVE UP. If you or a loved one is suffering from any form of mental illness, it is so, so important to have annual physicals. Find a good doctor to be your primary care physician. You have to ask sometimes for this kind of blood work (it should be standard!!) I want to shout this message from the rooftops. No one should have to suffer in the dark like this.

  32. I have that mutation, it is not too uncommon. For the most part, physicians failed me. It’s good to discover it earlier–good for her and three cheers for her doctor. I succeeded despite my vague, lifelong struggle with “anemia”, but a bout of strep put me over the edge at one point. I found my way clear to a normal (even better) life after learning of this and the important vitamin supplements that relieve symptoms. Eat lots of greens!! You’ll be fine. Those of Southern Italy or Asian heritage are more likely to have this mutation–especially Southern Italy, but they eat greens like crazy, so they don’t generally suffer from the worst symptoms (neural tube pregnancy problems and miscarriage).

  33. I too suffered from anxiety for months and went to many doctors to diagnose me. I thought I was going crazy and my poor hubby didn’t know what to do. I couldn’t drive, be in a crowded area, and had a hard time breathing! I also had weird nerve twitching I can’t explain and insomnia. I did try the vitamins you e took. But I think mine is different. I am missing progesterone and you should have it along with estrogen. Dr. Told me to stay on the pill to keep me balanced. I was sad because I wanted another child. Well that went out the door! I also am on an antidepressant that works for anxiety and am slowly getting off of it. I’m back to normal and so glad you shared this. People who’ve. NEver had bad anxiety won’t know what you’ve been though. There is a light! Good for you Lo!

  34. I have the MTHFR mutation we like to call it the mother f$&@er mutation. Greener pastures FCO and seeking health Adeno B-12 has really helped me. Also πŸ™πŸΌ Please consider doing extensive research about this mutation and routine shots…. it’s really important for people with this mutation.

  35. Thank you for sharing your story with us. I’m happy to hear you didn’t give up & found answers that you needed. Does anyone have any reccomendations on getting genetic testing done? The $200 though 23andme.com is a bit high for my budget. I’ve suffered w anxiety for 17 yrs & depression the last couple. Postpartum after both my children. Taken anxiety medications in the past w little help & nothing for almost a year now. Low vitamin D discovered, but weekly pills haven’t made a difference from what I can tell. I truly feel like something is off. Even when I’m eating healthy, running & lifting weights. Any insight from others would be much appreciated. Thank you!

  36. The Perfect Condition vitamin sounds great BUT taking Folic Acid when you are MTHFR is a big no no. It’s bad for us and blocks the methylated folate you are also taking. Thanks for this article. Good stuff.

  37. i found your blog and video through yahoo news and love both and your openness in sharing your struggle and progress with anxiety and depression. its very informative and inspiring! I have subscribed to your channel, God bless you and all that you do!!!! Xo

  38. Lo – just wanted to thank you for posting such a meaningful video and bringing awareness to such an important issue that affects so many. I have a 2 yo son and my PPD/PTSD (triggered by a traumatic birth) didn’t hit me until he was a year old. My “Great Depression” also began in 2016 and has steadily gotten worse, although I would classify mine as more intense anxiety like you’ve described. I know the feeling of being trapped in the Hell that anxiety creates.
    Nevertheless, I am finally going to get full blood work done on Thursday to address this and will definitely ask about any vitamin deficiencies present thanks to your video. I wish I could tell you that someone mentioned this to me at some point, but sadly there’s still such a stigma around potential mental illnesses that most other new moms won’t bring it up…at least where I live. So THANK YOU again for bravely sharing your story and path to healing!

  39. I would recommend those of you who have the MTHFR mutation that you look into Mast Cell Activation Syndrome. Many MCAS sufferers are deficient in iron, Vit C, and Vit B. Dr. Afrin at University of Minnesota is the pioneer doctor who discovered MCAS. I am willing to bet when you read up on it you will recognize yourself in the symptoms. It was life changing for me when the Mayo clinic diagnosed me last year. So many problems I have had all my life were probably caused by MCAS. Too many people are written off as being depressed when in reality it is a medical problem.

    1. Rissa, what specialist at Mayo did you see? And what blood test do I need to ask for to reveal the vitamin deficiencies? All these symptoms sound like they’re running my life currently. I’m about to order the 23andMe to be sure. Thanks much!

      1. It was actually a neurologist who overseas my neurologist who thought that I might have it. The Mayo allergist has no clue. I am actually going next week to an allergist outside of Mayo who knows about it. But the tests they ran on me were Prostaglandins and tryptase- among other tests they were doing to search for a Pheocromocytoma. I have so many other health problems even among the rare I am rare. Most masties are low in iron, but because of my bone marrow transplant I am high. There is a wealth of information about it in this facebook group called Mast Movement. You can find out what tests you should ask for there. I hope it helps.https://www.facebook.com/groups/MastMovement/?ref=bookmarks

  40. Thank you so much for this post, Lo! I am 25 and have been battling with similar anxiety/ depression issues. You described it perfectly, in words I couldn’t find to express especially about the medication taking a long time to work. I found this post inspiring and helpful. I will try vitamins D because i have a deficiency of Vitamin D and it’s healthier than Medications. Lo, keep doing what you do cause you’re great. Thanks again!

  41. Thank you so much for this post, Lo! I am 25 and have been battling with similar anxiety/ depression issues. You described it perfectly, in words I couldn’t find to express especially about the medication taking a long time to work. I found this post inspiring and helpful. I will try vitamins D because i have a deficiency of Vitamin D and it’s healthier than Medications. Lo, keep doing what you do cause you’re great. Thanks again!!!

  42. Hey, Lo,
    What do you mean that you could have permanent brain damage if this doesn’t get fixed? I can’t find any articles about that. Do you know any articles or information as to what extent the damage does?

  43. I’m going through the same thing. I thought no one would understand, no one could possible go through it too. I could cry from relief and the feeling of hope. Thank you. I wish we could talk over tea or coffee. It would just make me feel like I’m not alone.

  44. This is something that I have experienced, potentially not to the same degree as you, but a similar experience nonetheless. Ialso went through a period of feeling abnormal when I was doing everything to make me feel normal. When finally starting a vitamin regime specifically designed for me, it made a world of a difference. It is always so uplifting to hear success stories of people who have been through similar things. Thanks for the post and honesty regarding a “taboo” subject that shouldn’t be that way.

  45. Hi Lo,I saw you today or someone who looked just like you in McDonald’s in Santa Clarita, CA. I racked my brain on where I’ve seen you before and remembered watching you years ago on TV. That’s how I stumbled onto your blog and it was meant for me to read! My daughter suffers from all of the symptoms you mentioned so I honestly believe God allowed me to see you today, whether it was just your doppelganger or really you πŸ˜‰ As a result I plan to get her some thorough testing. Thank you for your transparency that could lead to her overall health as a result of this Blog!
    God Bless!

  46. Thank you, thank you so much for sharing this difficult journey you have gone through. I also have the MTHFR gene mutation. I agree with everything you said! It is an absolutely horrible experience to go through but it has made me a better person also.As more people talk about this and share their experiences hopefully more doctors will start to acknowledge this gene mutation and treat us with respect instead of a acting like we are making up our symptoms.

  47. Hi Lo,Thank you for sharing!

    Were you worried what else your genetic test was going to reveal? I’m contemplating getting mine done for similar reasons as you but I’m a little nervous I might see something I don’t want to know.

    I actually know I have a MTHFR gene mutation and another gene mutation that could be contributing to my problems so idk if I have enough info or if I should dig deeper to end the guessing game?

  48. I just found out i actually have the exact same deficiencies. We were wondering why i was so up and down still after months of being on my anti depressant, but more alarmed when my hair started falling out. Hopefully i will have some amazing results just as you did.

    Thank you for sharing!

  49. Dear Lo, i have been battling major depression and anxiety for 3 years. My VitaminD levels since 2014 have been <4. My Dr. during that time verbally told me there is not enough scientific evidence to support all the ailments i had been feeling. I reed your article and changed Drs. I am now on a 50,000 iu prescription of Vitamin D3. Thank you for sharing your story and giving me the strength to fire my Dr. I hope I’m not too late and haven’t suffered permanent damage. I pray my depression will subside and the physical muscle pain and fatigue will end soon.
    Hopeful in Chino Hills.

  50. Hi Lo, my year of Great Depression/extreme anxiety + more was in 2013. Just this past summer (2017), I started seeing a naturopath and she recommended a b12 test. My level was at 142. I believe I had this deficiency since before 2013 but it wasn’t checked. I also have neurological symptoms now but I’m taking b12 injections so hopefully I don’t have permanent damage. Love your blog by the way!

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